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digoxin
Digoxin remains one of those fascinating cardiac glycosides we’ve used for centuries, originally derived from the foxglove plant (Digitalis lanata). It’s interesting how this medication has persisted through modern cardiology despite newer agents emerging. I still remember my first complex case with Mrs. Gable, a 72-year-old with persistent atrial fibrillation and heart failure - her story really cemented my understanding of this drug’s nuances. Digoxin: Precise Heart Rate Control for Heart Failure and Arrhythmias - Evidence-Based Review 1.
Aciphex: Potent Acid Suppression for GERD and Ulcer Healing - Evidence-Based Review
Rabeprazole sodium, marketed under the brand name Aciphex, represents a significant advancement in the proton pump inhibitor (PPI) class of medications. It’s specifically engineered to suppress gastric acid secretion by targeting the H+/K+ ATPase enzyme system at the secretory surface of the gastric parietal cell. Unlike earlier acid-suppressing agents, Aciphex provides more consistent and prolonged acid control, making it particularly valuable for managing various acid-related disorders. Its development addressed the need for faster onset of action and more predictable pharmacokinetics across different patient populations, including those with CYP2C19 genetic polymorphisms that affect metabolism of other PPIs.
adalat
Nifedipine, marketed under the brand name Adalat among others, is a calcium channel blocker medication primarily used in the management of hypertension and angina. It belongs to the dihydropyridine class and functions by relaxing blood vessels, thereby reducing blood pressure and improving blood flow to the heart muscle. The development of Adalat represented a significant advancement in cardiovascular therapeutics when it was first introduced, offering an alternative mechanism of action compared to beta-blockers and diuretics that dominated antihypertensive therapy at the time.
Alavert: Dual-Action Relief for Allergic Rhinitis Symptoms - Evidence-Based Review
Alavert represents one of the more interesting developments in over-the-counter allergy management we’ve seen in recent years. When loratadine first went OTC back in 2002, it was revolutionary - finally giving patients effective relief without the sedation of older antihistamines. But Alavert’s formulation with pseudoephedrine created this dual-action approach that actually made sense clinically. I remember when it first hit the market, several of us in the allergy clinic were skeptical about whether the combination offered meaningful advantages over taking the components separately.
Aldactone: Comprehensive Management of Fluid Retention and Hormonal Conditions - Evidence-Based Review
Spironolactone is a potassium-sparing diuretic that’s been around since the 1960s, originally developed as an anti-hypertensive but finding its real niche in treating conditions where aldosterone excess plays a pathological role. What’s fascinating is how this old drug keeps revealing new applications - from its classic use in heart failure to off-label uses in dermatology that nobody anticipated back when I was in medical school. I remember my first rotation in cardiology, watching my attending prescribe Aldactone for a patient with severe systolic heart failure.
aricept
Aricept, known generically as donepezil, is a centrally acting reversible acetylcholinesterase inhibitor approved for the treatment of Alzheimer’s disease. It’s one of the few medications that can modestly improve cognitive function and global clinical state in patients with mild to moderate Alzheimer’s, though it doesn’t change the underlying disease progression. We’ve been using it since the late 1990s, and it remains a first-line option despite newer agents emerging. 1. Introduction: What is Aricept?
calan
Calan, known generically as verapamil, represents one of the foundational calcium channel blockers in cardiovascular medicine. Initially developed in Germany during the 1960s, this phenylalkylamine derivative has maintained clinical relevance for decades due to its unique electrophysiological properties and vascular effects. Unlike dihydropyridine calcium channel blockers that predominantly affect vascular smooth muscle, verapamil exhibits significant activity on both cardiac myocytes and vascular tissue, creating a distinct therapeutic profile that continues to shape treatment algorithms for arrhythmias and hypertension.
clenbuterol
Clenbuterol hydrochloride is a beta-2 adrenergic agonist with structural similarities to epinephrine and salbutamol, though its pharmacological profile differs significantly from both. Originally developed and still legally approved in some countries as a bronchodilator for managing respiratory conditions like asthma in veterinary medicine, its off-label human use has become widespread despite lacking approval from major regulatory bodies like the FDA and EMA. The compound exists as a racemic mixture, with the (R)-enantiomer being the biologically active form responsible for its bronchodilatory and anabolic-like effects.
cordarone
Cordarone, known generically as amiodarone, remains one of the most paradoxically fascinating and clinically challenging antiarrhythmic agents in our cardiology toolkit. It’s a Class III antiarrhythmic with additional Class I, II, and IV properties, essentially a pharmacologic powerhouse for managing serious ventricular and supraventricular tachyarrhythmias. Despite its well-documented efficacy, its notorious side effect profile—particularly pulmonary toxicity and thyroid dysfunction—means we reserve it for refractory cases where other agents have failed. The drug’s extreme lipophilicity leads to extensive tissue distribution and an elimination half-life stretching up to 100 days, creating a “pharmacologic ghost” that lingers long after discontinuation.